Endocrine Abstracts

Pituicytomas are rare tumours, originating from modified glial cells called pituicytes. The lineage of these tumours remains a topic of debate. Approximately 65 cases have been reported in the literature to date, since being formally recognised in 2007. We report a case where the final diagnosis was made after second surgery for late recurrence.Case: A 54-year-old man presented with left sided visual disturbances in 1998 and underwent transcranial resect...

Introduction: Acromegaly is a rare, progressive disease characterised by excess growth hormone. The recommended treatment is surgery. Radiotherapy and somatostatin analogues are used as adjuncts. The risk of post-radiotherapy osteosarcoma is 0.01% to 0.03% among all irradiated patients. We report a case of radiation-induced osteosarcoma that developed 22 years after radiotherapy for acromegaly.Case report: In 1997, a 53-year-old gentleman with acromegaly...

Introduction: Clinically non-functioning pituitary adenoma (NFPA) represents up to 30% of pituitary tumours. Management is dictated by their size or mass effect. The natural progression of NFPA attracts debate as the evidence-base is limited.Methods: Conservatively managed NFPA patients were included. A single radiologist reviewed all images to avoid bias.Results: Forty-six patients were identified, 21 female. Four presented acutel...

Introduction: Incidental pituitary adenoma (IPA) is found in 10–20% autopsy and radiological series. These are being increasingly detected as access to sensitive imaging modalities improves.Methods: Patients with incidental pituitary findings between 2012 and 2016 were identified from local database. Referral details, clinical features and radiological findings were analysed. A single radiologist reviewed all images to avoid bias.<p class="abste...

Introduction: Non-functioning pituitary macroadenoma (NFMA) can cause considerable morbidity due to pituitary dysfunction and pressure effects. We present recent experience in managing cases diagnosed with NFMA at a single tertiary centre between January 2009 and October 2013.Results: Of the 63 patients with NFMA, 28 (44%) were females. Age ranged from 22 to 91 (mean 63). Visual disturbance symptoms (35/63; 57%) were the commonest presentation. Headache ...

Granulomatosis with polyangiitis (GPA), previously known as Wegener’s granulomatosis, is a rare heterogeneous vasculitic disease characterised by necrotising granulomatous inflammation typically affecting lungs and kidneys. GPA affecting pituitary is rare and usually results in posterior pituitary involvement causing diabetes insipidus. We describe a case of GPA, presenting with pituitary involvement causing headaches and anterior pituitary hormone deficiencies.<p cla...